Advancements in Extrusion-Spheronization. More agile techniques are improving the development of multiparticulate drug-delivery systems. Caleva Process Solutions Another resourceful Powerpoint Presentation from Caleva Process Solutions. These selection. Extrusion – to form rod shaped particles of uniform diameter. Spheronization – to round off these rods into spherical particles. Drying – to.
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The dry, mixed, powdery active substances are kneaded into a dough with a liquid. Read more about it here!
Overview of the Extrusion-Spheronization Process
Extrussion for An Account Already a member? The diameter of the openings in the extrusion plate or extrusion basket determines the strength of the elongated extrusion threads that result. You can disable cookies but parts of our website may not work. It is useful for making dense granules for controlled-release extrision oral dosage forms with a minimum amount of excipients, as well as multiparticulates used for immediate, extrusin, or sustained-release.
Extrusion / Spheronization – Glatt Integrated Process Solutions
The technology chosen is dependent upon multiple active ingredient and formulation criteria, e. Moistening the powder mixture, forming cylinder-shaped agglomerate through extrusion, breaking and rounding the extrudate to round pellets through spheronization, and drying the finished product. Common applications include delayed release, extended release, pulsatile release, and fixed dose combinations.
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Our Mini-tablets are a popular finished dosage form presentation and offers the benefits of multiparticulates while using established tableting technology.
This dough then pressed through an extruder. Capsugel has extensive experience in designing, formulating and scaling mulitparticulate dosage forms at spjeronization, pilot and commercial scales. In other industries, the size of the pellets can be several centimeters. Capsugel has extensive experience and capabilities in optimizing pediatric and multiparticulate formulations.
Extrusion & Spheronization Pharmaceutical Technology
Join us for the multiparticulates webinar, where key considerations in designing multiparticulate formulations and processing will be discussed spheroniztion representative case studies. The wet extrudate is added to an LCI Marumerizer QJT spheronizer equipped with a high speed spinning plate which forms uniform spheres from the extrudate “rope”.
The process consists of four process steps: Capsugel is well versed in using drug layering and modified-release coat layering to achieve a range of dissolution profiles in multiparticulate format.
The coated spheres may be used for encapsulation, compression, or direct packaging into sachets or pouches for dosing. Primary packaging spjeronization either vials or sachets and secondary packaging services are also available.
Capsugel offers a drug delivery technology to provide oral delivery with full enteric protection and rapid release in the upper gastrointestinal GI tract without the use of coatings.
The process consists of five operations.
For technical extruzion, the resulting pellets are larger than micrometers. The wet mass is added into an LCI Multigranulator MG 55 where it is forced through a specific screen to form cylindrical extrudates using either dome, radial or axial extrusion for process optimization.
Cookies allow us to give you the best browsing experience and help us to understand how you use our site. The final drying ensures the pellet hardness.
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The spheres may undergo additional processing steps to apply functional or cosmetic coatings using fluid bed processing with a Wurster insert.
Even if the ball-shaped spgeronization is imperfect, the evenness of the surface still creates good conditions for subsequent coating. The ratio of liquid to solid material together with the size of the extruder holes significantly determines the quality of the extrudates.